• Providing clear sections on aspects of cell biology and biochemical engineering used in pharmaceutical process development and manufacturing, this source
• describes manipulations and the genetic engineering of cells for the production of biotechnology products
• outlines novel techniques for the development of serum-free and chemically defined media formulations
• addresses glycosylation and post translation of proteins and their importance for product quality
• presents guidelines for upstream and downstream process development for the production of cell culture based pharmaceuticals
• offers detailed guidance on the operation of bioreactors and production facility design
• presents a comprehensive outline for drug formulation
• decribes the design of aeration, mixing, and process control for batch and perfusion bioreactors
• details the optimization of protein expression from transient, batch, and perfusion systems
• offers discussions on the use of mammalian cells, insect cells, and stem cells
• discusses the emerging field of tissue engineering and its applications in the development of cell based therapies

This reference presents a comprehensive overview of the state-of-the-art in cell culture technology. Each expertly written chapter covers research, principles, and equipment currently affecting advances in the discovery of genes, host cell selection, cloning and gene amplification, bioreactor design, protein purification, optimization and scale-up, product quality, and facility design--showcasing the importance of genomic and cell-based technologies in the pharmaceutical industry.